CT/MRI, endoscopic ultrasonography and functional imaging using Octreoscan localise and stage disease. Pancreatic neuroendocrine tumours (panNETs) arise sporadically or as part of a genetic predisposition syndrome. Change in management occurred in 71% patients, and 57% of patients showed symptom improvement.Ħ8-Gallium DOTATATE PET-CT imaging is useful in detecting NETs in symptomatic patients with negative anatomical imaging and changes the treatments in these patients. Of the biochemically negative patients (n = 11), 68-Gallium DOTATATE PET-CT identified NETs in 64% (n = 7). Of the patients identified by 68-Gallium DOTATATE PET-CT, 50% (n = 1) had a treatment change and 100% showed symptom improvement. Of the biochemically positive patients (n = 11), 18% (n = 2) had additional evidence of NETs based on 68-Gallium DOTATATE PET-CT. Retrospective analysis of 22 of 196 patients with carcinoid-like symptoms and no evidence of primary neuroendocrine tumor (NET) based on anatomical imaging and endoscopy who underwent 68-Gallium DOTATATE PET-CT as part of a prospective clinical trial. The study's aim was to determine the utility of 68-Gallium DOTATATE positron emission tomography (PET)-CT scanning in patients with carcinoid-like symptoms and negative anatomical imaging. Significantly alter management recommendations. Integrated into radiologic screening and surveillance of patients with MEN1, as it can SPECT/CT and CT scan in patients with MEN1. Seen on 111In- pentetreotide SPECT/CT and CT scan.Ĭonclusions: 68Gallium-DOTATATE PET/CT is more sensitive for detecting NETs than 111Inpentetreotide Recommendations as a result of the findings on 68Gallium-DOTATATE PET/CT that were not In 8 of the 26 patients (31%), there was a change in management SPECT/CT, and in 10 patients (38.5%), additional metastases were detected (rangeĠ.3 cm to 1.5 cm). Patients (27%), 68Gallium-DOTATATE PET/CT was positive with a negative 111Inpentetreotide Lesions detected on 68Gallium-ĭOTATATE PET/CT had high SUVmax (median SUVmax = 72.8 ). Results: 68Gallium-DOTATATE PET/CT detected 107 lesions 111In- pentetreotide SPECT/CTĭetected 33 lesions and CT scan detected 48 lesions. SPECT/CT, and triphasic CT scan to clinical, biochemical and pathological data in Study design: Prospective study comparing 68Gallium-DOTATATE PET/CT, 111Inpentetreotide SPECT/CT and anatomic imaging in patients with MEN1. To prospectively determine the accuracy of 68Gallium-DOTATATE PET/CT versus 111Inpentetreotide The utility of somatostatin receptor imagingĦ8Gallium-DOTATATE PET/CT in patients with MEN1 is not known. Result in significant morbidity and mortality. Neoplasia type 1 (MEN1) is recommended to detect primary and metastatic tumors, which can Background: Screening for neuroendocrine tumors (NETs) in patients with multiple endocrine
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